Exbio — Research products — Antibodies — CD and related antigens — Anti-Hu PDPN (cancer type) Purified

Anti-Hu PDPN (cancer type) Purified

Regulatory status

RUO

Antigen

PDPN (cancer type)

Clone

LpMab-23

Format

Purified

Reactivity

Human

Application

IHC, WB, FC (QC tested)

Variant

0.1 mg

11-900-C100

In stock

154.00 USD

Variant

0.1 mg

11-900-C100

In stock

154.00 USD

Contact distributor

Product details

Description

References

SDS download

Isotype

Mouse IgG1 kappa

Specificity

The mouse monoclonal antibody LpMab-23 recognizes an extracellular epitope on human cancer type PDPN, a transmembrane glycoprotein, serving as a prognostic marker of oral carcinoma. This antibody recognizes an altered glycosylation pattern that occurs on oral cancer cells and it shows minimal reactivity with the surrounding non-cancerous tissue.

Application

IHC, WB, FC (QC tested)

Application details

Flow cytometry: Recommended dilution: 1-5 μg/ml.

Reactivity

Human

Immunogen

recombinant human PDPN

Concentration

1 mg/ml

Preparation

Purified by protein-A affinity chromatography.

Formulation

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Storage and handling

Store at 2-8°C. Do not freeze.

The product is intended For Research Use Only. Diagnostic or therapeutic applications are strictly forbidden. Products shall not be used for resale or transfer to third parties either as a stand-alone product or as a manufacture component of another product without written consent of EXBIO Praha, a.s. EXBIO Praha, a.s. will not be held responsible for patent infringement or any other violations of intellectual property rights that may occur with the use of the products. Orders for all products are accepted subject to the Term and Conditions available at www.exbio.cz. EXBIO, EXBIO Logo, and all other trademarks are property of EXBIO Praha, a.s.

Other names

podoplanin, AGGRUS, OTS8, T1A2, T1A1

Antigen description

PDPN (podoplanin) is a type I transmembrane glycoprotein of mucin-type character. The specific function of this protein has not been determined, but its homologs in other species were described as differentiation antigens. PDPN can be used as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified.

Entrez Gene ID 10630

UniProt ID Q86YL7

Product specific references:

Miyazaki A, Nakai H, Sonoda T, Hirohashi Y, Kaneko MK, Kato Y, Sawa Y, Hiratsuka H: LpMab-23-recognizing cancer-type podoplanin is a novel predictor for a poor prognosis of early stage tongue cancer. Oncotarget 2018 Apr 20;9(30):21156-21165.
PubMed

Furusawa Y, Yamada S, Nakamura T, Sano M, Sayama Y, Itai S, Takei J, Harada H, Fukui M, Kaneko MK, Kato Y: PMab-235: A monoclonal antibody for immunohistochemical analysis against goat podoplanin. Heliyon 2019 Jul 10;5(7):e02063. doi: 10.1016/j.heliyon.2019.e02063
PubMed